/ · 1894 Brewer’s · Q · Quarto
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A book half the size of folio-i.e. where each sheet is folded into quarters or four leaves. 4to is the contraction. (The Italian, libro in quarto; French, in quarto; from Latin quartus.)
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Entry taken from Dictionary of Phrase and Fable, edited by the Rev. E. Cobham Brewer, LL.D. and revised in 1895.